| abstract |
(57) [Summary]nRecombinant nucleic acids encoding all or part of epothilone polyketide synthase (PKS) for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants In addition, it is used to express a recombinant PKS gene in a host cell. The recombinant nucleic acid comprises a nucleotide sequence encoding at least one domain of an epothilone polyketide synthesis (PKS) protein and / or a nucleotide sequence encoding a functional region of an epothilone modifying enzyme. |