| abstract |
(57) [Summary]nThe present invention relates to gene transfer and gene therapy methods. More specifically, the present invention provides compositions and methods for targeted virus delivery. The method used is a mixture of a virus, which may be a recombinant virus, expressing the protein or nucleic acid of interest, and a cell targeting ligand, such as transferrin. The virus and ligand are mixed without a cross-linking agent or an agent that covalently links the virus and ligand. This simple mixing results in less inactivation than chemically binding the ligand to the virus, and thus results in a more active therapeutic composition than obtained by the method using a cross-linking agent. |