| abstract |
(57) Abstract: The compounds of the present invention are useful in inhibiting thrombin and related thrombotic occlusions and are compounds having structure (I) or pharmaceutically acceptable salts thereof, wherein b Is NY 1 or O; c is CY 2 or N; d is CY 3 or N; e is CY 4 or N; f is CY 5 or N; g is CY 6 or N Y 4 , Y 5 , and Y 6 are independently hydrogen, C 1-4 alkyl, or halogen; Y 1 and Y 2 are independently hydrogen, C 1-4 alkyl, C 3 -7 cycloalkyl, halogen, NH 2, OH or C 1-4 alkoxy, and Y 3 is hydrogen, C 1-4 alkyl, C 3-7 cycloalkyl, halogen, -CN, NH 2, OH or It is a C 1-4 alkoxy; A is (II), (III), ( V), it is a (V) or (VI); and W, W 1, R 1, R 3, R 4, R 5, X and Z are defined in the specification. Embedded image Embedded image |