| abstract |
(57) [Summary]nThe present invention relates to novel nitrosated and / or nitrosylated non-steroidal anti-inflammatory compounds, and at least one nitrosated and / or nitrosylated non-steroidal anti-inflammatory compound, and optionally, nitric oxide. Novel compositions comprising at least one of the compounds that donate, transfer or release, increase endogenous levels of endothelium-derived relaxing factor, stimulate endogenous production of nitric oxide, or are substrates for nitric oxide synthase About. The present invention also provides a method of treating, preventing and / or reducing inflammation, pain and fever; a method of reducing or restoring gastrointestinal, renal or other toxicities due to the use of non-steroidal anti-inflammatory drugs; treating and / or treating gastrointestinal disorders Methods for preventing; methods for treating inflammatory disease states and disorders; and methods for treating and / or preventing ocular diseases or disorders. |