| abstract |
(57) [Summary]nAntisense oligonucleotides useful for treating disease states characterized by p53 induction, such as proliferative cell disorders (eg, cancer or hypoxia induced by ischemic stroke such as stroke) Is described. The antisense agent is preferably of the class known as “steric blocker” type oligonucleotides, which include morpholino oligonucleotides, peptide nucleic acids, 2′-O-allyl or 2′-O -Alkyl modified oligonucleotides or N3 '→ P5' phosphoramidate oligonucleotides. |