| abstract |
(57) [Summary]n【Task】nThe cloning strategy used to obtain the full-length cDNA and deduced amino acid sequence for the controtrostatin precursor used the native controstatin amino acid sequence. The precursors include multidomain protein proproteins, metalloproteinases, and disintegrins (controstatins). The sequence can be used, upon expression, to create a recombinant DNA molecule encoding a control trostatin protein containing biologically active variants and fragments. When formulated as a pharmaceutically acceptable composition, the protein can be used to treat a patient by inhibiting the disease process associated with integrin binding to the integrin receptor. |