http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002526104-A
Outgoing Links
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|---|---|
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| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0623 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 |
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0797 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-00 |
| filingDate | 1999-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2002526104-A |
| titleOfInvention | Transplantable neural progenitors and stem cells for treatment of brain tumors |
| abstract | (57) [Summary]nOne of the obstacles to the treatment of some human brain tumors (eg, gliomas) is the extent to which they expand, migrate widely, and invade normal tissues. We show that tumor cells that expand extensively and aggressively advance while continuing to express foreign reporter genes when a clone of pluripotent neural progenitor stem cells are transplanted into experimental gliomas Demonstrate that they can move along the tumor along with and distribute themselves throughout the tumor. Moreover, the neural progenitor cells migrate slightly beyond and around the borders of the invasive tumor, somewhat drawn by the degenerative environment created just beyond the edge of the invasive tumor. When implanted at a site at a distance from the tumor bed (eg, in normal tissue, in the contralateral hemisphere, in the lateral ventricle), the donor neural progenitor / stem cells migrate through the normal tissue and target the tumor cells specifically. Can be targeted. These results suggest new neural progenitor / stem cells, effective delivery vehicles to help target therapeutic genes, and the adjunct use of vectors for invasive brain tumors that were resistant to treatment . |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007506754-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014133090-A1 |
| priorityDate | 1998-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 435.