http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002526067-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2799-026 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1205 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| filingDate | 1999-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2002526067-A |
| titleOfInvention | REC2 kinase |
| abstract | (57) [Summary]nThe invention includes a method of phosphorylating a serine-containing substrate by incubating the substrate with ATP and an enzyme that is hsRec2 or muRec2 or a derivative thereof. Natural substrates for the kinase activity of Rec2 are cell cycle regulatory proteins such as p53 and cyclin E. Overexpression of Rec2 is known to cause cell cycle arrest and apoptosis, and the present invention discloses that these effects are mediated by kinases. Thus, the present invention provides a method for evaluating Rec2 antagonists and agonists that will have pharmacological activity. Further, the invention discloses that there is specific binding between hsRec2 and at least three cell cycle regulatory proteins, p53, PCNA and cdc2. |
| priorityDate | 1998-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 248.