| abstract |
(57) The present invention relates to a phenylalanine derivative represented by the formula (1), and a salt, solvate, hydrate and N-oxide thereof: Wherein Ar 1 is an aromatic or heteroaromatic group; L 1 is a linker atom or group; R is a carboxylic acid or a derivative thereof; Ar 2 is optionally substituted Aromatic or heteroaromatic groups. These compounds can inhibit the binding of alpha4 integrin to its ligand and are used for prevention and treatment in immune or inflammatory disorders. |