| abstract |
(57) [Summary]nThe present invention relates to 1,4-benzodiazepines or 1,4-benzothiazepines derivatized with peptides, which can inhibit the interaction between annexin and annexin binding protein. Specifically, HBsAg of HBV, glycoprotein B of cytomegalovirus or annexin binding protein derived from influenza virus, a 1,4-benzodiazepine derivative capable of inhibiting the interaction between annexin binding protein of a virus and annexin Or a 1,4-benzothiazepine derivative. Diseases involving interactions between members of the annexin family and annexin binding proteins, such as HBV and / or HDV infection, using these 1,4-benzodiazepine or 1,4-benzothiazepine derivatives To prevent or treat cytomegalovirus infection or influenza virus infection. The invention also relates to annexin binding epitopes from HBsAg and their use in treating viral infections. |