| abstract |
(57) Abstract The present invention relates to a G protein-coupled EDG6 receptor and its fragments, variants and mutations, and uses thereof. Fields of application of the invention include molecular biology, pharmaceuticals and medicine. It is an object of the present invention to isolate and identify alternative members of the EDG receptor family and make them available for medical purposes. The novel human EDG6 receptor contains 384 amino acids of sequence 1 with seven transmembrane domains. The receptor has one possible N-terminal glycolysis site, three possible palmitoylation sites of 12 to 15 amino acids at the C-terminal position of the seventh transmembrane domain, and four possible C-terminal protein kinases It has a C phosphorylation site. The invention also relates to the use of the EDG6 receptor, fragments, variants and mutations thereof, and binding partners for therapeutic methods and treatment. |