| abstract |
(57) [Summary] Consensus sequence X 1 X 2 X 3 NNX 4 TX 5 X 6 X 7 X 8 (SEQ ID NO: 4) (where X 1 is a hydrophobic amino acid (leucine, isoleucine, valine, tyrosine, tryptophan) , phenylalanine or methionine), X 2 is a hydrophobic amino acid, X 3 is aspartic acid, glutamic acid, lysine or arginine, N is the asparagine, X 4 is any amino acid, T is threonine, X 5 is glutamic acid or aspartic acid, X 6 any amino acid, X 7 hydrophobic amino acids, X 8 has a hydrophobic amino acid), cyclic neurotrophic analgesic peptides derived from the active region of prosaposin. The peptides are useful for promoting nerve growth, preventing cell death, promoting myelination, treating neurodegenerative disorders and treating and preventing neuropathic pain. |