abstract |
(57) Abstract: A compound of formula I wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and Ar are as defined above. Is useful for treating conditions selected from the group consisting of arthritis, cancer and other diseases, characterized by matrix metalloprotease or mammalian reprolysin activity. In addition, the compounds of the present invention can be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAID's), COX-2 inhibitors and analgesics, and for the treatment of cancer such as adriamycin, daunomycin, cisplatin , Etoposide, taxol, taxotere and other cytotoxic drugs such as other alkaloids such as, for example, vincristine. Embedded image |