| abstract |
(57) [Summary]nThe present invention provides a mutilin having a 2-fluoro substituent or a 14-acyloxy derivative of 19,20-dihydromutilin, represented by structural formulas (a) and (b), 1 Is vinyl or ethyl; a Provided is a compound wherein COO- is an acyloxy group. The acyloxy group is HOCH 2 CO 2 -, RX-CH 2 -CO 2 -, R 2 − (CH 2 ) m -X- (CH 2 ) n -CH 2 CO 2 -Or carbamoyl. The compounds are useful for treating microbial infections in animals, especially humans and domestic mammals.nEmbedded image |