| abstract |
(57) [Summary] (Modified)nHypericin has been shown to specifically inhibit T-type calcium channel activity. Hypericum extracts, including hypericin, also inhibit T-type calcium channel activity. In addition, other chemicals in the hypericum extract showed a synergistic effect on hypericin. In this respect, hypericin or hypericin extract containing hypericin can be used as a T-channel blocker. Hypericin extracts, extracts of other species of Hyperisum, extracts of other plants containing hypericin, hypericin analogs such as hypericin derivatives, pseudohypericin, and other components of hypericum extract are associated with T-channel abnormalities Can be used for treatment targeting T-type calcium channels. Methods of administering hypericin and hypericum extract are disclosed. |