http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002520025-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6475 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate | 1999-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2002520025-A |
| titleOfInvention | Mammalian DED-Caspase Homolog Usalpin |
| abstract | (57) Abstract The protein Usurpin, an endogenous mammalian regulator of the apoptotic cell suicide process, is provided. Three usalpin proteins resulting from alternative splicing of the usalpine gene are provided. The full-length usalipin polypeptide (usalpin-α) is common to procaspases 8 and 10, including a tandem “deseffector domain” (DED) at the N-terminus and a caspase-like domain consisting of a large / small subunit. However, full-length usalpin lacks the key residues required for the proteolytic activity of caspases. However, usalpin heterodimers with procaspase-8 in vitro and prevents recruitment of procaspase-8 by the FADD / MORT1 adapter protein, thereby implicating a key interaction in the CD95 (Fas / APO-1) apoptotic process. To block. Therefore, usalpine is useful as a modulator of cell sensitivity to CD95 (Fas / APO-1) -mediated apoptosis. Accordingly, the present invention also provides a method of modulating apoptosis by introducing a Usalpine polypeptide into a cell. Also provided are various purified nucleotide sequences encoding usalpine. Also provided is a method of identifying an inhibitor of the interaction between usalpine and procaspase-8. Such inhibitors control the interaction of Usalpin with procaspase 8 and are therefore useful for modulating apoptosis. |
| priorityDate | 1998-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 243.