| abstract |
(57) Abstract The present invention relates to novel multi-binding compounds that bind to potassium (K + ) channels and regulate their activity. The compounds of the present invention comprise from 2 to 10 K + channel ligands covalently linked by a linker, wherein the ligands, in the monovalent (ie, unlinked) state, have one or more To the K + channel. The manner in which these ligands are linked together is such that the multi-binding agent so formed has a higher biological effect as compared to the same number of unlinked ligands that are provided to bind to K + channels. And / or show a therapeutic effect. The present invention also relates to methods of using such compounds and methods of preparing them. The compounds of the present invention are particularly useful for treating mammalian diseases and conditions mediated by K + channels. Accordingly, the present invention also relates to a pharmaceutical composition comprising a pharmaceutically acceptable excipient and an effective amount of a compound of the present invention. |