| abstract |
(57) [Summary]nDisclosed are multiple binding compounds including macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptogramins, tetracyclines, and / or other compounds. These compounds bind to bacterial ribosomal RNA and / or one or more proteins, which are involved in ribosomal protein synthesis in bacteria, and are useful for treating bacterial infections. These compounds have a deleterious effect on protein expression and have antibacterial effects. The multibinding compounds of the present invention comprise 2 to 10 ligands covalently linked to one or more linkers. Each ligand is a macrolide antibiotic, an aminoglycoside, lincosamide, oxazolidinone, streptogramin, tetracycline, or other compound, wherein the compound is a bacterial ribosomal RNA and / or one or more proteins ( Ribosomes involved in protein synthesis in bacteria). |