http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002516338-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| filingDate | 1999-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2002516338-A |
| titleOfInvention | Agents as inhibitors of cell migration and / or focal adhesion that interfere with the binding of protein tyrosine phosphatase PEST to signal proteins |
| abstract | (57) SUMMARY The present invention interferes with the binding of protein tyrosine phosphatase PEST (PTP-PEST) to signaling molecules involved in cell migration, focal adhesion and / or cell proliferation, ie, p130cas and paxillin. To a compound or drug. Such agents can be derived from the minimal sequence found in binding studies. PTP-PEST is a conserved phosphatase required for embryo differentiation. Knockout cells (PTP-PEST − / −) are obtained by immortalization of null embryos, in which abnormalities in cell migration, focal adhesion and cell proliferation are observed. Therefore, an agent capable of interfering with the activity of PEST in an affected target tissue is a potential agent for treating a disease caused by any phenomenon selected from the group consisting of cell proliferation, cell migration, inflammation and angiogenesis. Pharmaceutical composition. Furthermore, the present invention relates to a method for detecting a true enzyme substrate for an enzyme, that is, phosphatase, by a method combining a method for producing a knockout by gene targeting and a substrate trapping technique using a substrate-binding inactivated mutant enzyme. . By using the method of generating knockouts by gene targeting, there is less detection of erroneous results than other techniques for artificially increasing nonspecific hyperphosphorylation levels (eg, methods using vanadate compounds). |
| priorityDate | 1998-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 995.