abstract |
(57) [Summary]nAccording to the present invention, there are provided various methods for modulating the expression of a foreign gene in a mammalian subject using a modified ecdysone receptor. Further, modified ecdysone receptor, and homomonomeric and heterodimeric receptors containing the same, nucleic acids encoding the modified ecdysone receptor of the present invention, modified hormone response elements, gene transfer vectors, recombinant cells, And a transgenic animal containing a nucleic acid encoding a modified ecdysone receptor of the invention. |