| abstract |
(57) [Summary]nThe selected novel substituted pyrimidinones and pyridone compounds are effective in preventing and treating TNF-α, IL-1β, IL-6 and / or IL-8 mediated diseases and other diseases such as pain and diabetes. The present invention provides novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, for the prevention and treatment of diseases and other diseases or conditions involving inflammation, pain, diabetes and the like, and pharmaceutical compositions, and , Including methods. The invention also relates to methods for making such compounds, as well as intermediates useful in such methods. |