| abstract |
(57) Abstract: Formula: Drug -P (= O) -O- linker (-R 2 ') k -R 2 [ wherein, drug -P (= O) -O- is, such as pamidronate or Hosukametto R 2 and R 2 ′ (if present) are independently acyl residues of aliphatic amino acids; linkers are esters of phosphonate, phosphinate or phosphoryl functions. At least a bifunctional moiety comprising an attached first functional group, and a second functional group esterified to R 2 spaced therefrom; and k is 1 or 0]. The compound has enhanced bioavailability or other pharmacokinetic function over the parent compound. |