http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002510489-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
| filingDate | 1999-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2002510489-A |
| titleOfInvention | Highly active interferon regulatory protein |
| abstract | (57) Abstract The present invention relates to an IRF protein modified in the carboxy-terminal domain (transactivation domain) by modification of the serine and / or threonine sites. The modification may be by phosphorylation of serine and / or threonine or by replacing serine and / or threonine residues with residues having acidic side chains, preferably carboxylic acid containing side chains such as aspartic or glutamic acid residues. Can be achieved. Such modified proteins can be variants of IRF-3 and IRF-7, chimeric proteins having both IRF-3 and IRF-7, and post-translationally modified (phosphorylated) IRF-3 proteins (the phosphorous Oxidation is induced by Sendai virus infection). More particularly, the present invention provides an altered interferon modulator (IRF) protein comprising at least one altered serine or threonine phosphoacceptor site in the carboxy-terminal domain, wherein the protein is preferably altered. Activation of the cytokine gene by the IRF is enhanced as compared to activation of the cytokine gene by the corresponding wild-type IRF protein. The present invention also provides pharmaceutical compositions containing the IRF protein, and uses of the protein, nucleotide sequences encoding it, and pharmaceutical compositions containing it. |
| priorityDate | 1998-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 306.