| abstract |
(57) [Summary]nThe present invention relates to a compound of formula (I) for the manufacture of a medicament for treating a patient suffering from HIV (human immunodeficiency virus) infection.nEmbedded imagen Wherein A is CH, CR Four Or N; n is 0-4; Q is hydrogen or -NR 1 R Two And R 1 And R Two Is hydrogen, hydroxy, C 1-12 Alkyl, C 1-12 Alkyloxy, C 1-12 Alkylcarbonyl, C 1-12 Alkyloxycarbonyl, aryl, amino, mono- or di (C 1-12 Alkyl) amino, mono- or di (C 1-12 Alkyl) aminocarbonyl, wherein each C 1-12 Alkyl can be optionally substituted; 1 And R Two Together form pyrrolidinyl, piperidinyl, morpholinyl, azide or mono- or di (C 1-12 Alkyl) amino C 1-4 Alkylidene can be formed; Three Is hydrogen, aryl, C 1-6 Alkylcarbonyl, optionally substituted C 1-6 Alkyl, C 1-6 Alkyloxycarbonyl; and R Four Is hydroxy, halo, optionally substituted C 1-6 Alkyl, C 1-6 Alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl, trihalomethyloxy; R Five Is hydrogen or C 1-4 L is an optionally substituted C 1- Ten Alkyl, C 3-10 Alkenyl, C 3-10 Alkynyl, C 3-7 Or L is -X 1 -R 6 Or -X Two -Alk-R 7 Where R 6 And R 7 Is optionally substituted phenyl; X 1 And X Two Is -NR Three -, -NH-NH-, -N = N-, -O-, -S-, -S (= O)-or -S (= O) Two And Alk is C 1-4 Aryl is an optionally substituted phenyl; Het is an optionally substituted aliphatic or aromatic heterocyclic residue; N-oxides thereof. , Pharmaceutically acceptable addition salts and the use of stereochemically isomeric forms. It further relates to novel compounds which are a subgroup of the compounds of formula (I), their preparation and compositions comprising them. |