http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002509699-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1241 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-711 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76 |
| filingDate | 1999-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2002509699-A |
| titleOfInvention | Mouse and human telomerase RNA component gene promoter regions |
| abstract | (57) Abstract The present invention relates to the identification of genomic promoter regions of human and mouse telomerase RNA genes. Telomerase activity is necessary for the unlimited growth potential of many human cancers. It is proposed that mutations or dysregulation of the telomerase repression pathway can cause reactivation or up-regulation of telomerase expression in cancer. The present invention provides details of elements important in the regulation of telomerase RNA genes, including Sp family transcription factors. The present invention also provides a method for screening for an element capable of suppressing telomerase RNA gene promoter activity, and use of the element in cancer treatment. In addition, it provides evidence for the development of new transcription-based cancer therapies and for a genetic approach to targeting therapeutic genes to cancer cells. That is, (1) disruption of the signal transduction pathway that regulates transcriptional repression and telomerase activation, and (2) tumor-specific gene expression for gene therapy using the telomerase RNA gene promoter. |
| priorityDate | 1998-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1073.