http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002509081-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18 |
| filingDate | 1999-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2002509081-A |
| titleOfInvention | Enhanced pre-fertilization action of molecules involved in sperm-egg binding |
| abstract | (57) [Summary] Synthetic peptides that enhance the action before fertilization were produced by including additional amino acids at the carboxyl terminus of the previously disclosed synthetic peptides. An improvement in biological activity was shown over previously disclosed peptides. Direct comparison of previously known synthetic peptides and the extended peptides involved short-term exposure of sperm to one or the other peptide in vitro at several concentrations. Then, when the sperm was evaluated in vitro using the egg membrane substrate, an increased percentage of the sperm bound to cells exposed to the novel elongation peptide. Similarly, when fertilization of sperm after artificial insemination was the standard, a greater proportion of the eggs were fertilized by sperm exposed to the novel elongation peptide. In one preferred embodiment, the enhanced pre-fertilization effect is a peptide having a 68 amino acid sequence (SEQ ID NO: 1): Was achieved using |
| priorityDate | 1998-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.