http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002508945-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43504 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 |
| filingDate | 1998-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2002508945-A |
| titleOfInvention | Gamma-conopeptide |
| abstract | (57) [Summary]nThe present invention relates to relatively short peptides, about 25-40 residues in length, or analogs to the naturally available peptides, which are naturally available in trace amounts in the venom of the mussel, comprising three cyclized disulfides. It contains a bond and one or more gamma-carboxyglutamic acid residues. More specifically, the present invention provides a compound of the general formula (I): Xaa described herein. 1 -Cys-Xaa Two -Cys-Xaa Three −Xaa Four -Cys-Cys-Xaa Five -Cys-Xaa 6 -Cys-Xaa 7 (SEQ ID NO: 1); or represented by the general formula (II): Xaa described in the present specification. 1 -Cys-Xaa Two -Cys-Xaa Three −Xaa Four -Cys-Cys-Xaa Five −Xaa 6 -Cys-Xaa 7 -Cys-Xaa 8 (SEQ ID NO: 2); or represented by the general formula (III): Xaa described in the present specification. 1 -Cys-Xaa Two -Cys-Xaa Three −Xaa Four −Xaa Five -Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa 6 -Cys-Xaa 7 (SEQ ID NO: 3); or a compound represented by the general formula (IV): Xaa described in the present specification. 1 -Cys-Xaa Two -Cys-Xaa Three −Xaa Four −Xaa Five -Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa 6 -Cys-Xaa 7 (SEQ ID NO: 4); or, general formula (V) described in the present specification: Xaa 1 −Xaa Two -Cys-Xaa Three −Xaa Four -Phe-Xaa Five -Cys-Thr-Xaa 6 −Ser−Xaa 7 -Cys-Cys-Ser-Asn-Ser-Cys-Asp-Gln-Thr-Tyr-Cys-Xaa 8 -Leu-Xaa 9 (SEQ ID NO: 5). Furthermore, the present invention relates to specific γ-conopeptides, specific pro-γ-conopeptides and nucleic acids encoding the pro-γ-conopeptides. The present invention also includes pharmaceutically acceptable salts of conopeptides. These conopeptides are useful as agonists of neuronal pacemaker calcium channels. |
| priorityDate | 1997-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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