http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002505255-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-14 |
| filingDate | 1999-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2002505255-A |
| titleOfInvention | Therapeutic agent for human diseases based on β-catenin, its production and use |
| abstract | (57) [Summary]n The present invention relates to peptides and similar molecules derived from the LEF-1 / TCF-4 transcription factor for cancer therapy, especially for the treatment of colorectal cancer and melanoma. This peptide and similar molecules influence the interaction of β-catenin with LEF-1 / TCF. An essential part of the present invention is a peptide comprising a part of the LEF-1 / TCF-4 transcription factor and its variants and mutants. This peptide preferably consists of 10-40 amino acids in the N-terminal region of LEF-1 or TCF-4. The invention also includes peptides or similar molecules derived from the armadillo region of β-catenin identified as an interaction domain with LEF-1 / TCF, APC, conductin and E-cadherin. These peptides or similar molecules also inhibit the interaction of β-catenin with LEF-1 / TCF or increase cellular β-catenin levels, as in the case of APC or conductin. The latter molecules can be used for regulating tissue and organ formation, for example for promoting hair growth. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10300109-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013505300-A |
| priorityDate | 1998-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 539.