| abstract |
(57) Abstract: Formula I wherein X 1 and X 2 are the same or different and are hydrogen, a C 1 -C 6 -alkyl group, or a halogen atom, or a position adjacent thereto. In some cases, together with the carbon atom to which they are attached, form a fused phenyl ring, and R is an optionally substituted carbocyclic or heterocyclic saturated or unsaturated group. The use of the compounds to be prepared, as well as physiologically tolerable salts thereof, for the manufacture of a medicament for diseases which is regulated via the inhibition of phosphodiesterase by cyclic nucleotides, in particular by cyclic adenosine monophosphate. The disease is more particularly proliferative disorders (including tumors, lymphomas, leukemias, atherosclerosis, and glomerulopathy), impaired memory and / or learning (among others Alzheimer's disease), impotence, Erectile dysfunction and obesity, ischemic or thrombolytic disorders (such as coronary or cerebral infarction), and also serum disorders. |