| abstract |
(57) Abstract: Formula: D * -linker * (R 2 ') k -R 2 , wherein R 2 and (if present) R 2 ' are amide or ester residues of an aliphatic amino acid. And k is 0 or 1, and D * is a drug residue having an available functional group selected from amine, hydroxy and carboxy, or a group capable of binding to the available functional group. Wherein the linker * is at least bifunctional, including a first functional group attached to the available functional group, separately from a second functional group forming an amide or acyl bond with an aliphatic amino acid. Sex linker. (Here, this compound does not contain a long-chain fatty acid ester.) However, when the drug contains a lactam carboxy or enolic hydroxy functional group, the linker * does not consist only of alkoxy, and the drug It is not a nucleoside having a hydroxyl group. ] The pharmaceutical compound shown by these, or its intermediate. |