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filingDate 1998-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2002-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2002501504-A
titleOfInvention Process for producing condensed polycyclic alkaloids by ring closure of azomethine ylide, novel compounds by the process and use of the compounds as chemotherapeutic agents
abstract (57) [Abstract] Azomethine ylide of the general formula (II): General formula (I) including a step of cyclizing Wherein A is a cyclic group which may be an aryl group or an aromatic heterocyclic group; or A is a cyclic group R A1 R A2 C-CR A3 R A4 (where R A2 and R A3 together with the carbon atom to which they are attached are optionally substituted to form a saturated or unsaturated carbocyclic or heterocyclic group, and R A1 and R A4 are as defined below, or Or A forms an acyclic group R A1 R A2 C-CR A3 R A4 wherein R A1 -R A4 are as defined below, and R A2 and R A3 are optional. Z is a carbon or a heteroatom; n is selected from 0, 1, 2 or 3; and R A1-A4 , W, X and Y are the same Each may be hydrogen, an optionally substituted alkyl, an optional Optionally substituted alkenyl, optionally substituted alkynyl, optionally protected hydroxy, optionally substituted amino, optionally substituted alkoxy, optional An optionally substituted alkenoxy, an optionally substituted alkynoxy, an optionally substituted aryl, an optionally substituted heterocyclyl, carboxy, carboxyester, carboxamide, acyl, Selected from acyloxy, mercapto, optionally substituted alkylthio, halogen, nitro, sulfate, phosphate, and cyano, or wherein W and X together with the nitrogen and carbon atoms to which they are each attached are optional. Or optionally saturated or A nitrogen-containing heterocyclic group which may be fused with a saturated carbocyclic group, an aryl group or a heterocyclic group), or a pharmaceutically acceptable derivative and salt, racemate, isotope and / or tautomer thereof. A method for producing a compound which is
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