| abstract |
(57) Abstract: A compound of the formula I which inhibits proteases including cathepsin K: Wherein R 1 is an aromatic or heteroaromatic ring; R 2 and R 3 are H, C 1 -C 8 alkyl, aryl, aryl C 1 -C 8 alkyl or heteroaryl; R 4 is aromatic A ring or a heteroaromatic ring or an amine; W, X, Y are independently selected from the group consisting of CH, N, S or O; provided that at least one of W, X and Y is heterocyclic Atoms], pharmaceutical compositions of such compounds, and diseases of excessive bone loss or cartilage or matrix degeneration including osteoporosis; gingival diseases including gingivitis and periodontitis; arthritis, osteoarthritis and chronic joints Rheumatism; Paget's disease; Malignant hypercalcemia; and associated metabolic bone disease treatments. |