| abstract |
(57) Abstract A phenylalanine derivative of formula (1), and salts, solvates and hydrates thereof, are described. Wherein L 1 is a linker atom or group; A is a chain-[C (R 7 ) (R 8 )] p Y [C (R 9 ) (R 10 )] q- where Y Is a sulfur atom or a —S (O) — group or a —S (O) 2 — group, and R 7 , R 8 , R 9 , and R 10 are the same or different and are each a hydrogen atom or a linear or May be a branched alkyl, or an optionally substituted aromatic group, or R 7 and R 8 are associated with the carbon atom to which they are attached, or R 9 and R 10 are the carbon atoms to which they are attached. With the atoms each forming a C 3-7 cycloalkyl group, and p and q being the same or different, each being 0 or an integer 1 or 2, and when either p or q is 0, the other is an integer 1 or 2; L 2 is -C (O) -, - C (O) O-, C (S) -, - S (O) 2 -, - CON (R 11) - [ wherein, R 11 is hydrogen atom or a straight or branched alkyl group], - CSN (R 11) - , —SON (R 1 ) —, or SO 2 N (R 11 ) —; R is carboxylic acid or a derivative thereof. The compounds of the invention can inhibit the binding of alpha 4 integrin to its ligand, and may be used in the prevention and treatment of immune or inflammatory disorders. Embedded image |