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publicationDate 2002-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2002500200-A
titleOfInvention Topical ophthalmic remedies including immunosuppressants
abstract (57) [Summary]nA therapeutic agent for topical ophthalmic treatment, comprising 0.02 to 5.0% by weight of an immunosuppressant belonging to the group consisting of monocyclic undecapeptides, macrolide lactones or corticosteroids, It is a therapeutic agent containing up to 10% by weight of a polyalkylene glycol-polyurethane copolymer as an agent. In the case of a hydrophilic base, the polyalkylene glycol-polyurethane copolymer comprises poly (oxy-1,2-ethanediyl) -α-hydro-ω-hydroxy polymer and 1,1′-methylene-bis- (4-isocyanate). And a copolymer having a weight average molecular weight of 1,000 to 3,000, and in the case of a lipophilic base, polyalkylene glycol-polyurethane copolymer is preferably poly [oxy (methyl-1,2-ethanediyl). )] It is preferable to comprise a copolymer of -α-hydro-ω-hydroxy polymer and 1,1′-methylene-bis- (4-isocyanatocyclohexane) having a weight average molecular weight of 1600 to 18000. The therapeutic agent may further include a common excipient in a topical administration form.
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