| abstract |
(57) [Problem] To provide a preventive / therapeutic agent for Alzheimer's disease, particularly familial Alzheimer's disease. SOLUTION: Insulin-like growth factor I (IGF- I) is the insulin-like growth factor I receptor (IGF-I R) via the Alzheimer V642I mutant APP Cell death of des (1-3) IGF- I suppresses cell death in the presence of IGFBP-3 in the same manner, and demonstrates that IGF-IR, particularly V922E-IGF-I R is Alzheimer's V642 even in the absence of IGF-I It was confirmed that cell death caused by the I mutant APP was suppressed. These IGF-I, des (1-3) IGF-I, IGF-IR, V922E-IGF-IR and the like are used as preventive / therapeutic agents for Alzheimer's disease. |