| abstract |
(57) [Summary] (Modified) [PROBLEMS] To provide a new apoptosis inducer comprising a compound safe for the human body. An apoptosis-inducing agent comprising an orostanal represented by the formula 1 or a synthetic analog of orostanal represented by the formula 2, or a pharmacologically acceptable salt thereof. (In the formula 2, R is a hydroxyl group, a lower alkoxy group which may have a substituent (methoxy, ethoxy, propyloxy, butyroxy, etc.), a lower acyloxy group which may have a substituent (acetoxy, ethoxycarbonyl) ), An amino group, a lower alkylamino group (such as methylamino, ethylamino, or isopropylamino), a di-lower alkylamino group (such as dimethylamino or diethylamino), or a 5- to 6-membered nitrogen-containing heterocyclic ring (pyrrolidine-1) -Yl, piperidino, morpholino, 4-morpholylcarbonyl, piperazin-1-yl, 4-methylpiperazin-1-yl, 4-ethylpiperazin-1-yl)) |