| abstract |
(57) [Problem] To provide an industrially advantageous method for producing carbapenems. A compound (I) of the following formula [R 1 is an OH protecting group] And (i) N, N'-carbonyldiimidazole or (ii) In the presence of a base, a halogenated carbonate and imidazole are added, and then an inorganic salt and R 2 OOCCH 2 COOH [R 2 is C OOH protecting group], an azide compound, an acid, a ring closure reaction, and then R 3 OH [R 3 is an acyl group] or a reactive derivative thereof, the method for producing a compound (VIII) of the following formula. Embedded image |