| abstract |
PROBLEM TO BE SOLVED: To provide a drug which selectively suppresses the production of IL-4, which is particularly involved in the pathogenesis and progression of allergic diseases, among cytokines produced from Th2 cells. Aim. SOLUTION: General formula (I) (Wherein, R 1 represents halogen, alkyl, alkoxy or the like, ring Q represents benzene or a heteroaromatic ring which may have a substituent, R 2 represents hydrogen, alkyl, or the like, Z represents CH or N, R 3 is halogen, cyano, nitro, amino, R 5 is alkyl, group: N (R 6 ) (R 7 ) (wherein R 6 and R 7 are the same or different and each represents hydrogen, It represents an alkyl or the like, or a group in which R 6 and R 7 together with an adjacent nitrogen atom form a cyclic amine. And the like). Or a pharmaceutically acceptable salt thereof. |