| abstract |
(57) [Summary] (Modified)n[PROBLEMS] To inhibit protein tyrosine kinase Therefore, new compounds useful for the treatment of cancer and malignant tumors provide.nA substituted heterocycle represented by the following general formula (I) Compounds and salts or solvates thereof, wherein Y is CR 1 And V is N or CR 2 And R 1 Is CH 3 SO 2 CH 2 CH 2 NHCH 2 -Ar- (where Ar is substituted Or unsubstituted furan or thiazole), R 2 Is Hydrogen, halogen, hydroxy, alkyl having 1 to 4 carbon atoms Kill, alkoxy, alkylamino, dialkylamino U is a phenyl group substituted with a benzyl group, etc. Alternatively, it is a 1H-indazolyl group or the like. ] And its It consists of a manufacturing method and a pharmaceutical preparation. |