| abstract |
(57) [Problem] To provide a novel androgen receptor action inhibitor having high antiandrogen activity, stability and safety. The present invention provides an androgen receptor action inhibitor comprising 5-hydroxyflavone as an active ingredient. [Effect] 5-Hydroxyflavone which is an active ingredient of the androgen receptor action inhibitor of the present invention exhibits a very high androgen receptor action inhibitory activity. Further, flavonoids including 5-hydroxyflavone are widely contained in tissues of plants to be eaten, and the androgen receptor action inhibitor of the present invention has high safety. For this reason, The androgen receptor action inhibitor of the present invention has high safety and is useful for preventing and / or treating androgen-dependent diseases such as hirsutism, acne (acne vulgaris), and male pattern baldness. |