| abstract |
(57) [Summary] (Modifications) [PROBLEMS] A method for suppressing nerve damage resulting from glucose and / or oxygen damage to the brain in a mammal, and primary hyperalgesia, secondary hyperalgesia in a mammal, Provided are methods for preventing primary allodynia, secondary allodynia, or other pain caused by central sensitization. The method comprises administering to a mammal an amount of an NR2B subunit-selective NMDA antagonist prior to impairment of glucose and / or oxygen supply to the brain, wherein the amount is an amount effective to inhibit nerve damage. It is. Methods of pain prevention include administering an amount of an NR2B subunit selective NMDA antagonist to a mammal prior to the pain affliction, wherein the amount is an amount effective to prevent the pain. |