| abstract |
(57) [Problem] To provide an excellent preventive or therapeutic agent for tachykinin-mediated diseases. A medicament containing a compound of the following general formula (I) or a pharmacologically acceptable salt, ester or other derivative thereof as an active ingredient: ｛R 1 : alkyl, R 2 : substituted 5-membered nitrogen-containing heteroaryl, substituted nitrogen-containing 5-membered heterocyclyl, R 3 : substituted-aryl, substituted heteroaryl, A: CO, SO 2 , E: CH 2 , O, S, G: substitutable cycloalkane ring, substitutable cycloalkene ring, substitutable saturated heterocyclic ring, Ar: substitutable aryl ring, substitutable heteroaryl ring, m: 1, 2, n: 2-4. ｝. |