| abstract |
(57) [Problem] To provide a starting material used for synthesis of a quinolone antibacterial agent. SOLUTION: Formula (II) A nitrobenzene having a compound represented by the formula (III) wherein X is chloro or fluoro is reacted with a suitable carbanion. (Wherein one of Y and Z is chloro and the other is nitro, R represents -CCl 3, -CH 2 NO 2, -CH (N O 2 ) R 1 , —CH (CO 2 R 1 ) 2 , —CH (C (O) R 2 ) 2 , —CH (CN) CO 2 R 1 , —CH (CO 2 R 1 ) a radical selected from the group consisting of COR 2 and —COR 2 (wherein R 1 is alkyl or arylalkyl, R 2 is alkyl, aryl or arylalkyl, and when it appears more than once in the radical R 1 and R 2 may in each case be the same or different)) 2-chloro- A process for producing 4,5-difluorobenzoic acid and 2,4,5-trifluorobenzoic acid, and synthetic intermediates useful for and produced according to the process. |