| abstract |
PROBLEM TO BE SOLVED: To provide a method for micronizing a polypeptide without any denaturation, which is simple, rapid, and has a high recovery rate. SOLUTION: A polypeptide-insoluble water-miscible organic solvent is added to a frozen product of an aqueous solution containing a polypeptide and a phase separation inducing agent, and the phase separation inducing agent and ice in the frozen product are melted to obtain a polystyrene. Obtain peptide microparticles. |