abstract |
(57) [Problem] To provide a physiologically active substance having a novel molecular skeleton exhibiting proteasome inhibitory activity. SOLUTION: General formula (I) (Wherein, in the MK600-A substance, R 1 is an isopropyl group and R 1 2 is a methyl group; in the MK600-B substance, R 1 is a phenyl group and R 2 is a methyl group; in the MK600-C substance, R 1 is an isopropyl group and R 2 is an ethyl group; D In the substance, R 1 is a phenyl group and R 2 is an ethyl group, Me represents a methyl group) MK600- A, B, C and D were obtained by culturing Streptomyces sp. MK600-CF7 as a novel bioactive substance. MK600-A, Each of the substances B, C and D has a proteasome inhibitory activity. |