http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002275156-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ead90443277482e25bf91bfddef2b5a7 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-90 |
| filingDate | 2001-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f936ba0be41d879b239a85a5df91773e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac045a488a2cd0e7c49f06f5b4ae6c3d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3e5ded0cdddce900d599e7ca16b2673 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7d840dcf1fc595b1b04374ede570081 |
| publicationDate | 2002-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2002275156-A |
| titleOfInvention | Method for producing 1,4-dihydropyridine monoester derivative |
| abstract | PROBLEM TO BE SOLVED: To obtain an asymmetric 1,4-dihydropyridine-3,5-dicarboxylic acid diester having a blood pressure lowering action and a vasodilator action in high purity. SOLUTION: The following formula (I): (Wherein, Ar represents an aryl group which may have a substituent, and R 1 and R 2 independently represent an alkyl group having 6 or less carbon atoms). By decomposition, 1,4-dihydropyridine in which one R 1 is replaced by H In producing the 3,5-dicarboxylic acid monoester derivative, 0.8 to 2.0 moles of a metal hydroxide catalyst, 10 to 50 moles of water and 1 to 20 times by weight of diesters are used as OH groups per mole of diesters. The reaction is performed in the presence of a polar organic solvent. |
| priorityDate | 2001-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.