| abstract |
PROBLEM TO BE SOLVED: To screen a compound having an antibiotic activity in infection, dysfunction and disease involving Streptococcus pneumoniae, and to a factor which can be used to measure a role in its pathogenesis. There is a request. The present invention provides a MurA-1 polypeptide and a DNA (or R) encoding such MurA-1. NA) and methods of producing such polypeptides by recombinant techniques, and methods of using MurA-1 for the treatment of infections, particularly bacterial infections. Also disclosed are such antagonists that antagonize MurA-1 and their use as therapeutics to treat infections, especially bacterial infections. |