| abstract |
PROBLEM TO BE SOLVED: To provide a novel condensed thiophene derivative as an agent for preventing or treating bone or joint diseases, an industrially advantageous production method thereof and a novel production intermediate. SOLUTION: General formula (I) [In the formula, R 1 represents an optionally substituted hydrocarbon residue, a heterocyclic group, a sulfinyl group, a sulfonyl group, a hydroxyl group, a thiol group or an amino group, and R 2 represents a cyano group, a formyl group, a thioformyl group. And the ring A is (Wherein, R 3 represents a hydrogen atom, an optionally substituted hydrocarbon residue, a heterocyclic group, a hydroxyl group, an amino group, a sulfonyl group or an acyl group, and R 14 represents a hydrogen atom, a halogen, etc.) It represents an aromatic 5-membered heterocyclic ring, and ring B represents an optionally substituted 5- to 7-membered hydrocarbon ring. Or a salt thereof, a production intermediate thereof, a production method, and a pharmaceutical composition comprising a compound represented by the general formula (I) as an active ingredient. |