| abstract |
(57) [Summary] (Modified) [PROBLEMS] To treat diseases of the CNS and other diseases in mammals by administering a central nervous system (CNS) -penetrating α7 nicotinic receptor agonist to mammals including humans And a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a CNS-penetrating α7 nicotinic receptor agonist. A compound represented by the following general formula: Or a mirror image thereof, a diastereomer or a tautomer, Or a pharmaceutically acceptable salt of such a compound or isomer [where n = 1-2: m = 1-2: o = 1-2: A = O, S or NR 1 ; Q = N or CR 3 E = N Or CR 5 B = N or CR 2 D = N or CR 4 ]. In particular, 1,4-diaza-bicyclo [3.2.2. ] Nonane derivatives. |