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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-24
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filingDate 2001-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bbd3b2141f4197d35533edc2dc974db
publicationDate 2002-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2002249463-A
titleOfInvention Process for producing optically active compounds that efficiently removes chiral auxiliary groups
abstract (57) [Problem] To improve the usefulness or adaptability of an optically active compound by efficiently removing a chiral auxiliary group used in asymmetric synthesis from an asymmetric synthesis product. SOLUTION: An asymmetric ester (A 1 ) having two asymmetric sources is reacted with sodium methoxide in the presence of dimethyl carbonate according to the following reaction formula (1) to give an asymmetric ester ( A method for producing an optically active compound by removing a chiral auxiliary group from an asymmetric synthesis product comprising producing B 1 ) and oxazolidinone or an analog thereof (C 1 ). In the formula (1), R represents a functional group or an atomic group containing an asymmetric source constituting the desired optically active compound; Represents a hydroxyalkylamide or an oxazolidinone type chiral auxiliary, and n is an integer of 2 to 4. Embedded image
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